A selection of our work!

More @ https://www.ncbi.nlm.nih.gov/myncbi/1fSX1TXLu4UAd/bibliography/public/

Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors

Braun TP, Estabrook J, Schonrock Z, Curtiss BM, Darmusey L, Macaraeg J, Enright T, Coblentz C, Callahan R, Yashar W, Taherinasab A, Mohammed H, Coleman DJ, Druker BJ, Demir E, Lusardi TA, and Maxson JE. Leukemia. 2022. DOI: 10.1038/s41375-022-01792-x

Mutant-SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms.

Carratt SA, Kong GL, Curtiss BM, Schonrock Z, Maloney L, Maniaci BN, Blaylock HZ, Baris A, Druker BJ, Braun TP, Maxson JE. Blood. 2022. DOI: 10.1182/blood.2021014777.

GoPeaks: histone modification peak calling for CUT&Tag.

Yashar WM, Kong G, VanCampen J, Curtiss BM, Coleman DJ, Carbone L, Yardimici GG, Maxson JE, Braun TP. Genome Biology. 2022. DOI: 10.1186/s13059-022-02707-w.

Mutant SETBP1 enhances NRAS-driven MAPK activation to promote aggressive leukemia.

Carratt SA, Braun TP, Schonrock Z, Callahan R, Smith B, Coblentz C, Maloney L, Foley AC and Maxson JE. Leukemia. 2021. DOI: 10.1038/s41375-021-01278-2.

Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia.

Braun TP, Coblentz C, Smith BM, Coleman DJ, Schonrock Z, Carratt SA, Callahan RL, Maniaci B, Druker BJ, Maxson JE. PNAS. 2020. DOI: 10.1073/pnas.1918307117.

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia.

Braun TP, Okhovat M, Coblentz C, Carratt SA, Foley A, Schonrock Z, Nevonen K, Davis B, Garcia B, LaTocha D, Weeder BR, Grzadkowski MR, Estabrook JC, Manning HG, Watanabe-Smith K, Smith JL, Leonti AR, Ries RE, Jeng S, McWeeney S, Di Genua C, Drissen R, Nerlov C, Meshinchi S, Carbone L, Druker BJ and Maxson JE. Nature Communications. 2019. DOI: 10.1038/s41467-019-13364-2.

A novel germline variant in CSF3R reduces N-glycosylation and exerts potent oncogenic effects in leukemia.

Spiciarich DR, Oh ST, Foley A, Hughes SB, Mauro MJ, Abdel-Wahab O, Press RD, Viner R, Thompson SL, Chen Q, Azadi P, Bertozzi C, Maxson JE.  Cancer Research. 2018.
DOI: 10.1158/0008-5472.CAN-18-1638.

Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML.

Maxson JE, Jason Gotlib JR, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney S, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW.
The New England Journal of Medicine. 2013.
DOI: 10.1056/NEJMoa1214514.